PIPELINE

Autoimmune Indications:

Multiple sclerosis (MS), Sjogren’s syndrome (SS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes (T1D), others.

Solid Tumor Indications:

Hepatocellular carcinoma (HCC), non-small cell lung cancer (NSCLC), colorectal cancer (CRC), others.

ABS-066 is a splicing-modulating antisense oligonucleotide that reduces the expression of sIL7R by correcting the alteration in alternative splicing that produces it.

ABS-2005 is the first monoclonal antibody that specifically inhibits sIL7R while sparing the membrane-bound IL7R.

ABS-001 is a splicing-modulating antisense oligonucleotide that enhances the expression of sIL7R by increasing the splicing alteration that produces it.